How Aflatoxins (黄曲霉素) Cause Liver Cancer?
Aflatoxins are a group of toxins produced by certain molds, primarily Aspergillus flavus and Aspergillus parasiticus, which grow in soil, decaying vegetation, grains, and nuts. These toxins are known to contaminate food supplies, particularly in warm and humid regions. Aflatoxin exposure is a major health concern because of its potent carcinogenic effects, particularly related to liver cancer.
How Aflatoxins Cause Liver Cancer:
- Liver Damage and Carcinogenesis:
- When aflatoxins are ingested, the liver metabolizes them into reactive compounds, including aflatoxin B1 (AFB1), which is the most toxic.
- Aflatoxin B1 gets converted into a reactive form by enzymes in the liver. This form can bind to DNA, causing mutations in the p53 tumor suppressor gene. This leads to uncontrolled cell growth and the development of hepatocellular carcinoma (HCC), a common form of liver cancer.
- Synergy with Hepatitis:
- The risk of liver cancer is significantly higher when aflatoxin exposure is combined with chronic hepatitis B (HBV) or C (HCV) infection. Aflatoxin-induced DNA damage, coupled with viral infection, accelerates cancer development.
- Foods at Risk:
- Foods like maize (corn), peanuts, tree nuts, and grains are particularly susceptible to aflatoxin contamination, especially in regions where storage practices are poor, leading to mold growth.
Prevention:
- Regulation and Monitoring: Many countries regulate aflatoxin levels in food and animal feed to reduce the risk of contamination.
- Improved Storage: Keeping crops dry and storing them in proper conditions can help prevent aflatoxin-producing molds from growing.
- Detoxification Methods: Some efforts are being made to develop food treatments to detoxify aflatoxins, but these are not widely available.
Long-term exposure to high levels of aflatoxin is strongly associated with liver cancer, particularly in areas with high rates of aflatoxin contamination and hepatitis B infection.
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